Articles



From Concept to Biomarkers: An MRM Approach to Clinical Cancer Marker Discovery
2018-05-31

Efforts in discovering biomarkers from liquid biopsies with sufficient performance to be clinically useful remain a significant challenge in diagnostics. However, as detailed in this example, researchers can leverage highly multiplexed approaches to simultaneously measure a multitude of proteins.

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Predictive Modeling Pitfalls: Information Leakage Can Generate Models that Fail to Validate with New Data
2018-05-30

Building predictive models that successfully generalize to new data is a challenging process full of potential pitfalls. During the modeling building process, cross-validation is routinely used to optimize parameters, and importantly, provide an independent assessment of trained model performance using the hold-out test set partitions.

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Discovering The Hidden Signal Among the Noise: An In Silico Example
2017-11-09

Deomstrating a method for identifying biomarkers that interact, or represent the effects of a biological network. When combined, often out perform multivariate canidates idetified by ANOVA anlysis.

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Collect Your Own Proteome: Demonstrating the Feasibility of Personal Proteome Data Collection and Analysis
2018-03-17

Consumer-level personalized health monitoring is rapidly advancing as technology and public interest in this area continues to grow. Here, we demonstrate the feasibility for individuals to measure their own proteome, utilizing existing sample collection methods, contract research laboratories, and open source software.

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Consideration of HDF5 File Architecture for LCMS Data Acquisition Archival and Efficient Access
2018-01-06

Open access data efforts for LCMS are not fully optimized for big data applications. Proposed here is a file architecture utilizing the HDF5 accessable file format.

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